Exposure to Potential CYP450 Pharmacokinetic Drug-Drug Interactions among Osteoarthritis Patients: Incremental Risk of Multiple Prescriptions
نویسندگان
چکیده
منابع مشابه
Exposure to potential CYP450 pharmacokinetic drug-drug interactions among osteoarthritis patients: incremental risk of multiple prescriptions.
Patients taking more than one drug metabolized through the cytochrome P450 (CYP450) enzyme system experience a drug-drug exposure (DDE), which puts them at risk for a potential pharmacokinetic drug-drug interaction (DDI), defined as two or more drugs interacting in such a way that the effectiveness and/or toxicity of one or all drugs are changed. Any patient subjected to a DDE is at risk for a ...
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Drug-drug interactions (DDIs) have been defined as two or more drugs interacting in such a way that the effectiveness and/or toxicity of one or all drugs are changed. Patients taking more than one drug metabolized through the cytochrome P450 (CYP450) enzyme system, including some, but not all, opioids experience a drug-drug exposure (DDE), which may result in a potentially dangerous DDI. Using ...
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ژورنال
عنوان ژورنال: Pain Practice
سال: 2010
ISSN: 1530-7085
DOI: 10.1111/j.1533-2500.2010.00438.x